Creatine Monohydrate
N-(Aminoiminomethyl)-N-methylglycine monohydrate
Amino acid derivative for ATP regeneration in muscle. No FDA RDI; declared with † symbol. Typical dose 3-5 g per day.
FDA Reference Data
About Creatine Monohydrate
Creatine Monohydrate is the most researched sports supplement ingredient, used to increase phosphocreatine stores in skeletal muscle for ATP regeneration during high-intensity exercise. As an amino acid derivative, it has no FDA-established RDI and is declared with the † symbol on Supplement Facts labels. Typical maintenance doses are 3-5 g per day; loading protocols use 20 g/day for 5-7 days. The compound is typically declared in grams (g) on Supplement Facts panels due to the large dose size. Creatine Monohydrate is the gold-standard form; other forms (HCL, ethyl ester) lack equivalent research support.
Common Supplement Forms
Frequently Asked Questions
How do I declare creatine on a Supplement Facts label?
Declare "Creatine Monohydrate [amount] g†" with the † symbol indicating no established Daily Value. The legend "Daily Value not established" must appear at the bottom of the Supplement Facts panel. Amounts are typically declared in grams (g) due to the 3-5 g typical dose. The form (monohydrate, HCL, etc.) is part of the ingredient name on the same row, not separated into an ingredient list entry.
Is creatine mandatory on Supplement Facts labels?
No. Creatine is a voluntary-declaration ingredient per FDA 21 CFR 101.36(b)(2). It only appears on the Supplement Facts panel if the product contains it. There is no FDA-established RDI for creatine, so the † symbol is required and no %DV value is calculated.
What is the typical creatine monohydrate dose on a Supplement Facts label?
The standard maintenance dose is 3-5 g per day, typically declared as "Creatine Monohydrate 5 g†" on the Supplement Facts panel. Some products use a loading phase (20 g/day for 5-7 days, divided into 4 doses), which should be reflected in the serving size and directions for use. The FDA does not restrict maximum creatine dose in dietary supplements.
Should I declare creatine as monohydrate or just "Creatine"?
The full name "Creatine Monohydrate" should be used because it identifies the specific form. Different creatine forms (monohydrate, HCL, ethyl ester) have different properties and bioavailability. FDA 21 CFR 101.4 requires the common or usual name of the ingredient, and "Creatine Monohydrate" is the established common name for this specific compound.
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